Non-steroidal anti-inflammatory drugs (NSAIDs) are often used in the treatment of pain by their analgesic, anti-inflammatory, and antipyretic properties. NSAIDs act via inhibition of cyclooxygenase enzymes, COX-1, COX-2 and COX-3. In this study, the antinociceptive activity of the dextrorotatory enantiomers of S (+) configuration of ketoprofen, denominate, dexketoprofen (DEX), was evaluated, before and after the pretreatment of mice with N(ω)-nitro-L-arginine methyl ester (L-NAME), in two models of pain. In one model of tonic pain, the tail-flick (TF) assay, and in a second model of phasic pain, the acetic acid writhing test (WT). (DEX) administration produced a dose-dependent antinociceptive effect in both murine assays, but with different potency. The dose that produced 50 % of the maximum possible effect (ED50) of antinociception of the WT was 3.87-fold more potent than TF. The pretreatment of mice with 1, 3, or 10 mg/kg, i.p of L-NAME produced a significant decrease of the antinociceptive effect of DEX, reflected with an important increase of ED50 in both assays. In conclusion, the results the application of DEX produced antinociception in the WT and TF models, and in this effect, the activation of the NO pathway plays an important role.
Amlodipine besylate is a long-acting calcium channel blocker which has proved to be very potent in the curation of elevated blood pressure. It is a relatively new antihypertensive drug which is commonly prescribed as a single oral dose. Eleven (11) male wistar rats of 250g average body weight were used to determine the effect of Amlodipine besylate on the male reproductive hormones. Three dose levels (0.5, 1.0 and 10mg/kg) were used. The rats were all sacrificed on the eight day following treatment and the serum collected was sent for hormonal assay. The results obtained showed normal values of the reproductive hormones when compared with the control. This study strongly suggests that there was no significant reduction in the values of the reproductive hormones even at the highest dose administered. It could be said that Amlodipine besylate is good for the treatment of hypertension.
The Editor in Chief, Journal of Experimental Research Department of Anatomy, Enugu State University of Science and Technology, College Of Medicine (ESUCOM), GRA Enugu, Nigeria.
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Enugu State University of Science and Technology