ATERE AD, AKOBI TE, OYOVWII MO, KOSAMAT YA

• access_time5 July, 2025

  subjectCategory: Medical Laboratory Sciences

• Menopause induces hormonal changes, potentially leading to oxidative stress and inflammation, contributing to various health risks. This study aimed to investigate the relationship between oxidative stress, inflammation, and menopause-related physiological changes in women. A comparative cross-sectional study was conducted on 100 women aged ≥ 30 years, subdivided into postmenopausal (PMP), premenopausal (PRM), and reproductive women age (RWA). Serum levels of oxidative stress and antioxidant markers (SOD, MDA, GPx, CAT, H O ) and 2 2 acute phase reactants (CRP, SAA) were measured using standard spectrophotometric and immuno assay techniques. Statistical analysis was performed using SPSS 25.0. PMP women exhibited significantly higher levels of oxidative stress markers (MDA, H O ) and acute phase reactants (CRP, SAA) compared to PRM and 2 2 RWA (p<0.05). Conversely, enzymatic antioxidants (SOD, GPx, CAT) were significantly lower in PMP women (p<0.05). CRP showed superior diagnostic performance than SAA, with higher AUROC values (0.937 vs. 0.737). Menopause is associated with increased oxidative stress and inflammation, elevating the risk of cardiovascular diseases, osteoporosis and metabolic disorders. Early interventions targeting oxidative stress and inflammation are recommended to mitigate menopause-related health risks. Regular health screenings and lifestyle modifications emphasizing antioxidant-rich diets and physical activity are essential for women transitioning through menopause.
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