Edoga, C.O., Ezema, C.O. and Ogbonna, M.

• access_time15 February, 2024

  subjectCategory: Biological Sciences

• Antioxidant effect of the ethanolic extract of Ocimum gratissimium was investigated on the male Wistar albino rats infected with Ocimum gratissimium. Twenty-five (25) male albino Wistar rats were divided into five groups at random: the normal control group (rats that were neither infected nor treated), the negative control group (rats that were infected but not treated), the low-dose group (rats that were infected but treated with the extract at 2.5 mg/kg), the medium-dose group (rats that were parasitized and treated with extract at 5.0 mg/kg), and the high dose group (rats that were infected and treated at 7.5mg/kg). The antioxidant parameters such as superoxide dismutase, catalase, reduced glutathione, and lipid peroxidation product (malondialdehyde) were measured in the serum after 14 days of therapy in the experimental rats. The findings showed that the negative control group's activities of the enzyme's superoxide dismutase, catalase, and reduced glutathione were significantly lower than those of the normal control and treated groups (p<0.05). However, upon the administration of Ocimum gratissimium the parameters enzymes activities of the infected and treated groups significantly increased (p<0.05). This effect affirmed that the extract has antioxidative properties that reversed oxidative potentials caused by Plasmodium berghei infection.
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