Chukwu U.E. Aloh G.S, and Eze-Steven P.E.
  • access_time15 February, 2024

    subjectCategory: Clinical Sciences

  • Potassium bromate used widely in foods has been associated with various complications and much attention has been drawn to the toxic effect of bromate on the organs like liver, kidney etc. In this study, the effect of the ethanol extract of Anthocleista nobilis leaves on kidney and liver damages induced by exposure to an acute dose of potassium bromate was measured using appropriate biomarkers. Anthocleista nobilis, known commonly as Okpokoro, is extensively used in traditional medicine to treat many disorders. Potassium bromate was induced through oral administration followed by oral administration of ethanol extract of Anthoclesta nobilis at doses 200mg/kg body weight, 400mg/kg body weight for 4 weeks, while the control group received distilled water and the positive control group received the ascorbic acid and distilled water. At the end of the experiment, the rats were sacrificed, body weight, relative organ weight, the parameters of the lipid. Treatment with ethanol extract of Anthoclesta nobilis at doses of 200mg/kg body weight, 400mg/kg body weight and 800mg/kg body weight showed significant increase of the body weight in treated groups. Result shows a significant increase in RBC, PCV, Hb and a significant decrease in WBC and PLT. Result also showed a significant decrease in urea uric acid, creatinine, sodium, potassium, chlorine and bicarbonate at (p<0.05). This study revealed that Anthoclesta nobilis was efficient in reducing and management of potassium bromated induced systemic toxicity and be a potential source of control for oxidative stress caused some environmental oxidants.
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