Edoga CO,* Ezema CO, and Eze-Steven PE.

• access_time13 April, 2024

  subjectCategory: Biological Sciences

• This study was to determine the protective effects of Gongronema latifolium on male Wistar albino rats induced with indomethacin. Twenty-five (25) male Wistar albino rats weighing 150 g were used in this study. The rats were randomly selected and divided into five groups of five rats. Groups A, B and C were blank, negative and positive controls while Groups D and E were low (100 mg/kg) and high (400 mg/kg) dose treated groups of the extracts of Gongronema latifolium respectively. Rats were housed in metallic cages and allowed to acclimatize for fourteen days. The ulcerative index increased significantly in group B at (p<0.05) (68.00±2.83) but the low dose treated groups reduced significantly (p<0.05) after oral administration of 100 mg/kg of Gongronema latifolium extract at 12.00±4.24. The percentage ulcer inhibition increased significantly p<0.05 (77.68±4.61) when treated with standard anti-ulcer drug for the Group C. The percentage of ulceration reduced significantly (p<0.05) (38.26±6.09) when treated with low dose (100 mg/kg) of Gongronema latifolium for Group D. The pH value was at the lowest level at the negative control group (Group B) at (p<0.05) (2.92±0.63) but was significantly increased (4.60±0.18) (p<0.05) when treated with high dose of extracts of Gongronema latifolium. Indomethacin induced ulcer increased the mucosa acidity of Wistar albino rats (Group A) with the highest value (p<0.05) (5.29±0.12), but when treated with low dose (Group D) of Gongronema latifolium, it significantly reduced (2.75±1.061) (p<0.05). This study shows Gongronema latifolium is potent, effective and efficacious due to its phytochemical properties that have antioxidants potentials.
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