Amaralam, E.C ., Achi, N.K ., Oyedemi, S.O., and Aloh, G.S

• access_time12 April, 2025

  subjectCategory: Biological Sciences

• Wonderful kola (Buchholzia coriacea) is a plant use traditionally for treating diabetes, cold, cough and catarrh. The present study evaluates the possible hypoglycemic activity and ameliorating effects of oral administration of fructose-flavonoid rich seed extract of Buchholziacoriacea seeds, in Streptozotocin (STZ)-induced diabetic rats. A total of twenty five (25) rats where used for this study. They were divided into five (5) groups of five rats each; Normal control, negative control (Streptozotocin (STZ)-induced diabetic), positive control (Glibenclamide), 100mg/kg b.w. of the seed extract and 500mg/kg b.w. of the seed extract. Fasting blood glucose (FBG) levels were evaluated before and after extracts administration. The flavonoid extract significantly decreased (P<0.05) FBG in hyperglycemic rats as the weeks progresses after extract administration. The administration of flavonoid and Glibenclamide (standard antidiabetic drug) for 6 weeks significantly lowered (P<0.05) FBG level in STZ-induced diabetic rats. The extract significantly decreased (P<0.05) the elevated levels of serum total cholesterol, triglyceride and thiobarbituric acid reactive species (TBARS) products in diabetic rats. In conclusion, the results suggest that Buchholzia coriacea seeds contain a potent hypoglycemic and antilipidmic effects which will could be a scientific merit in the traditional use of the extract in the management of diabetes and the improvement of its complications.
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