Ugwuoke, M. C ,Aloh G.S. Ajima J. N., Anosike J.C.

• access_time12 April, 2025

  subjectCategory: Biological Sciences

• This study was to evaluate some Biochemical and Haematological effect of ethanol extract of Dialiumguineense stem bark in ethanol induced peptic ulcer in Albino rats. The stem bark of Dialiumguineense were collected at Mercy Girls High School Okigwe. Adult albino rats weighing (200-311kg) both sexes were obtained from the animal house of the Department of Zoology, University of Nigeria, Nsukka and used for the study. The animals were housed under standard conditions 12/13h light-dark cycle starting 8:00am at temperature of 25. The result of RBC, PVC and Hb and WBC showed no significant (P < 0.05) different in the groups treated with 200mg/kg, 400mg/kg and 800mg/kg body weight of an extract. PLT has no significant different (P < 0.05) in all the groups. In the MCV result, the omeprazole group, the ulcer group and groups treated with 200mg/kg, 400mg/kg, 800mg/kg body weight of an extract indicated no significant different and they are significantly(P < 0.05) `higher than the normal group. In liver markers, the albumin, ALP and total bilirubin showed no significant different (P < 0.05) in the omeprazole group, and the groups treated with 200mg/kg, 400mg/kg, 800mg/kg body weight of the extract. The total protein also showed no significant different (P < 0.05) in the groups treated with 200mg/kg, 400mg/kg, 800mg/kg body weight of Dialiumguineense stem bark. This study showed that Dialiumguineense stem bark is efficacious and effective due to its phytochemical properties that have antioxidant effects and ability to heal wound.
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